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Symbiosis Department - Publications

Publications of members of the Symbiosis Department


Berg J, Pjevac P, Sommer T, Buckner CRT, Hach P, Liebeke M, Danza F, Sengupta A, Tonolla M, Schubert C, Milucka J, Kuypers MMM. Dark aerobic sulfide oxidation by anoxygenic phototrophs in anoxic waters. Environmental Microbiology (under revision)


Puentes-Cala E, Liebeke M, Markert S, Harder J. Limonene dehydrogenase hydroxylates the allylic methyl group of cyclic monoterpenes in the anaerobic terpene degradation of Castellaniella defragrans. Journal of Biological Chemistry (under revision)


Puentes-Cala E, Liebeke M, Markert S, Harder J (2018). Anaerobic Degradation of Bicyclic Monoterpenes in Castellaniella defragrans. Metabolites 8 (1): 12 10.3390/metabo8010012

Pende N, Wang J, Weber PM, Verheul J, Kuru E, Rittmann SK-MR, Leisch N, VanNieuwenhze MS, Brun YV, den Blaauwen T, Bulgheresi S (2018). Host-Polarized Cell Growth in Animal Symbionts. Current Biology. In press.
  Bang C, Dagan T, Deines P, Dubilier N, Duschl WJ, Fraune S, Hentschel U, Hirt H, Hülter N, Lachnit T, Picazo D, Pita L, Pogoreutz C, Rädecker N, Saad MM, Schmitz RA, Schulenburg H, Voolstra CR, Weiland-Bräuer N, Ziegler M, Bosch TCG (2018). Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?. Zoology. In press.
  Bergin C, Wentrup C, Brewig N, Blazejak A, Erséus C, Giere O, Schmid M, de Wit P, Dubilier N (2018). Acquisition of a novel sulfur-oxidizing symbiont in the gutless marine worm Inanidrilus exumae. Applied and Environmental Microbiology 84(7): e02267-17
 2017 Ponnudurai R, Sayavedra L, Kleiner M, Heiden SE, Thürmer A, Felbeck H, Schlüter R, Sievert SM, Daniel R, Schweder T, Markert S (2017). Genome sequence of the sulfur-oxidizing Bathymodiolus thermophilus gill endosymbiont. Stand. Genomic Sci. 12: 50.
  Ponnudurai R, Kleiner M, Sayavedra L, Petersen JM, Moche M, Otto A, Becher D, Takeuchi T, Satoh N, Dubilier N, Schweder T, Markert S (2017). Metabolic and physiological interdependencies in the Bathymodiolus azoricus symbiosis. ISME J. 11: 463-477.
  Jäckle O (2017). Mund- und darmlos in den Sedimenten mariner Tropen - Symbiose macht´s möglich. In Klüger nutzen - besser schützen: Bremer Forschung an tropischen Küsten, Hempel G, Hempel I, Hornidge A-K, pp. 43–46. Bremen, Germany: Edition Falkenberg
  Avci B, Hahnke RL, Chafee M, Fischer T, Gruber-Vodicka H, Tegetmeyer HE, Harder J, Fuchs BM, Amann RI, Teeling H (2017). Genomic and physiological analyses of 'Reinekea forsetii' reveal a versatile opportunistic lifestyle during spring algae blooms. Environ Microbiol. 19(3):1209-1221. doi: 10.1111/1462-2920.13646
  Dubilier N (2017). High tide for marine microbes. Cell 169: 771.

Urbaniak T, Soto M, Liebeke M, Koschek K (2017). Insight into the mechanism of reversible ring-opening of 1, 3-benzoxazine with thiols. The Journal of Organic Chemistry 82(8): 4050-4055.


Tavormina PL, Kellermann MY, Antony CP, Tocheva E, Dalleska N, Jensen AJ, Valentine DL, Hinrichs K-U, Jensen G, Dubilier N, Orphan VJ (2017). Starvation and recovery in the deep-sea methanotroph Methyloprofundus sedimenti. Molecular Microbiology 103: 242-252.


Seah BKB, Schwaha T, Volland J-M, Huettel B, Dubilier N, Gruber-Vodicka HR (2017). Specificity in diversity: single origin of a widespread ciliate-bacteria symbiosis. Proceedings of the Royal Society B: Biological Sciences 284:20170764. doi:10.1098/rspb.2017.0764.
Rubin-Blum M, Antony CP, Borowski C, Sayavedra L, Pape T, Sahling H, Bohrmann G, Kleiner M, Redmond MC, Valentine DL, Dubilier N (2017). Short-chain alkanes fuel mussel and sponge Cycloclasticus symbionts from deep-sea gas and oil seeps. Nature Microbiology 2:nmicrobiol201793. doi:10.1038/nmicrobiol.2017.93.


Kreutzmann A-C, Dubilier N (2017). Dunkle Energie: Symbiosen zwischen Tieren und chemosynthetischen Bakterien. In Faszination Meeresforschung, Hempel G, Hagel W, Bischof K (eds), 2 edn, 22, pp 231–243. Berlin, Germany: Springer


Rochfort S, Bailey-Wyatt AM, Liebeke M, Southam AD, Viant MR, Bundy JG (2017). Novel aromatic metabolites from the coelomic fluid of Eisenia earthworm species. European Journal of Soil Biology 78:17e19


Lehnen N, Marchant H, Schwedt A, Milucka J, Lott C, Weber M, Dekaezemacker J, Seah BKB, Hach PF, Mohr W, Kuypers MMM (2016). High rates of microbial dinitrogen fixation and sulfate reduction associated with the Mediterranean seagrass Posidonia oceanica. Systematic and Applied Microbiology, 39 (7): 476-483. doi: 10.1016/j.syapm.2016.08.004


Petersen JM, Kemper A, Gruber-Vodicka H, Cardini U, van der Geest M, Kleiner M, Bulgheresi S, Mußmann M, Herbold C, Seah BKB, Antony CP, Liu D, Belitz A, Weber M (2016). Chemosynthetic sulphur-oxidizing symbionts of marine invertebrate animals are capable of nitrogen fixation. Nature Microbiology, 2: 16195. doi:10.1038/nmicrobiol.2016.195


Breusing C, Biastoch A, Drews A, Metaxas A, Jollivet D, Vrijenhoek RC, RC, Bayer, T, Melzner F, Sayavedra L, Petersen JM, Dubilier N, et al.  (2016). Biophysical and population genetic models predict the presence of ‘phantom’ stepping stones connecting Mid-Atlantic Ridge vent ecosystems. Curr Biol 26: 2257–2267.


Schimak MP, Kleiner M, Wetzel S, Liebeke M, Dubilier N, Fuchs BM (2016). MiL-FISH: Multilabeled oligonucleotides for fluorescence in situ hybridization improve visualization of bacterial cells. Appl. Environ. Microbiol. 82: 62–70.


Kreutzmann A-C, Schulz-Vogt HN (2016). Oxidation of molecular hydrogen by a chemolithoautotrophic Beggiatoa strain. Appl Environ Microbiol 82:2527–2536.


Leisch N, Pende N, Weber PM, Gruber-Vodicka HR, Verheul J, Vischer NO, Abby SS, Geier B, den Blaauwen T, Bulgheresi S (2016). Asynchronous division by non-ring FtsZ in the gammaproteobacterial symbiont of Robbea hypermnestra. Nat Microbiol 2:16182. 10.1038/nmicrobiol.2016.182


Montanaro J, Gruber D, Leisch N (2016). Improved ultrastructure of marine invertebrates using non-toxic buffers. PeerJ 4:e1860. DOI 10.7717/peerj.1860


Hao J, Liebeke M, Sommer U, Viant M, Ebbels T, Bundy JG (2016). Statistical correlations between NMR spectroscopy and direct infusion FT-ICR mass spectrometry aid annotation of unknowns in metabolomics. Analytical Chemistry 88 (5), 2583-2589


Spurgeon DJ, Liebeke M, Kille P, Anderson C, Lawlor A, Bundy JG, Lahive E (2016). Ecological drivers influence the distributions of two cryptic lineages in an earthworm morphospecies. Applied Soil Ecology 108, 8-15


Sahling H, Borowski C, Escobar-Briones E, Gaytán-Caballero A, Hsu C-W, Loher M, MacDonald, I, Marcon, Y, Pape, T, Römer, M, Rubin-Blum, M, Schubotz, F, Smrzka, D, Wegener, G, Bohrmann, G (2016). Massive asphalt deposits, oil seepage, and gas venting support abundant chemosynthetic communities at the Campeche Knolls, southern Gulf of Mexico. Biogeosciences 13: 4491–4512.


Assié A, Borowski C, van der Heijden K, Raggi L, Geier B, Leisch N, Schimak MP, Dubilier N, Petersen JM (2016). A specific and widespread association between deep-sea Bathymodiolus mussels and a novel family of Epsilonproteobacteria. Environ. Microbial. Reports. doi:10.1111/1758-2229.12442


Hamann E, Gruber-Vodicka H, Kleiner M, Tegetmeyer HE, Riedel D, Littmann S, Chen J, Milucka J, Viehweger B, Becker KW, Dong X, Stairs CW, Hinrichs KU, Brown MW, Roger AJ, Strous M (2016). Environmental Breviatea harbour mutualistic Arcobacter epibionts. Nature 534: 254-258.


Krukenberg V, Harding K, Richter M, Glockner FO, Gruber-Vodicka HR, Adam B, Berg JS, Knittel K, Tegetmeyer HE, Boetius A, Wegener G (2016). Candidatus Desulfofervidus auxilii, a hydrogenotrophic sulfate-reducing bacterium involved in the thermophilic anaerobic oxidation of methane. Environ Microbiol 18: 3073-3091.


Meier DV, Bach W, Girguis PR, Gruber-Vodicka HR, Reeves EP, Richter M, Vidoudez C, Amann R, Meyerdierks A (2016). Heterotrophic Proteobacteria in the vicinity of diffuse hydrothermal venting. Environ Microbiol 18: 4348-4368.


Zimmermann J, Wentrup C, Sadowski M, Blazejak A, Gruber-Vodicka HR, Kleiner M, Ott JA, Cronholm B, De Wit P, Erseus C, Dubilier N (2016). Closely coupled evolutionary history of ecto- and endosymbionts from two distantly related animal phyla. Mol Ecol 25: 3203-3223.


Okamura B, Gruhl A (2016). Myxozoa + Polypodium: A common route to endoparasitism. Trends in Parasitology, 32 (4), 268-271 doi:10.1016/


Berg JS, Michellod D, Pjevac P, Martinez‐Perez C, Buckner CR, Hach PF, Schubert CJ, Milucka J, Kuypers MM (2016). Intensive cryptic microbial iron cycling in the low iron water column of the meromictic Lake Cadagno. Environmental microbiology, 18(12), 5288-5302.


Wippler J, Kleiner M, Lott C, Gruhl A, Abraham PE, Giannone RJ, Young JC, Hettich RL, Dubilier N (2016) Transcriptomic and proteomic insights into innate immunity and adaptations to a symbiotic lifestyle in the gutless marine worm Olavius algarvensis. BMC Genomics 17:942. doi: 10.1186/s12864-016-3293-y


Seah BKB, Gruber-Vodicka HR (2015). gbtools: Interactive visualization of metagenome bins in R. Frontiers in Microbiology 6: 1451. doi:10.3389/fmicb.2015.01451


Sayavedra L, Kleiner M, Ponnudurai R, Wetzel S, Pelletier E, Barbe V, Satoh N, Shoguchi E, Fink D, Breusing C, et al, Dubilier N, Petersen JM (2015). Abundant toxin-related genes in the genomes of beneficial symbionts from deep-sea hydrothermal vent mussels. eLife 4:e07966 doi: 10.7554/eLife.07966


Liebeke M, Strittmatter N, Fearn S, McPhail D, Morgen J, Kille P, Fuchser J, Takats Z, Bundy JG (2015). Unique metabolites protect earthworms against plant polyphenols. Nature Communications 6, doi:10.1038/ncomms8869


Klose J, Polz MF, Wagner M, Schimak MP, Gollner S, Bright M (2015). Endosymbionts escape dead hydrothermal vent tubeworms to enrich the free-living population. PNAS 112: 11300–11305


Gruhl A, Schwaha T (2015). Bryozoa (Ectoprocta). In: Schmidt-Rhaesa A, Harzsch S, Purschke G (eds.) Structure and Evolution of Invertebrate Nervous Systems. Oxford University Press, pp. 325 - 340


Gruhl A (2015). Myxozoa. In Wanninger A (Ed.). Evolutionary Developmental Biology of Invertebrates 1: Introduction, Non-Bilateria, Acoelomorpha, Xenoturbellida, Chaetognatha. pp. 165–177. Springer-Verlag, Wien doi:10.1007/978-3-7091-1862-7


Kleiner M, Wentrup C, Holler T, Lavik G, Harder J, Lott C, Littmann S, Kuypers MMM, Dubilier N.: Use of carbon monoxide and hydrogen by a bacteria – animal symbiosis from seagrass sediments (2015). Environ. Microbiol. 17: 5023- 5035. doi:10.1111/1462-2920.12912


Dubilier N, McFall-Ngai M, Zhao L (2015). Create a global microbiome effort. Nature 526: 631-634


Hao,J., Liebeke, M., Deneiro, M., Astle, W., Bundy, JG., Ebbels T. (2014). Bayesian deconvolution and quantification of metabolites in complex 1D NMR spectra using BATMAN. Nature Protocols 9,1416–1427


Wentrup C., Wendeberg A., Schimak M.P., Borowski C., Dubilier N. (2014). Forever competent: deep‐sea bivalves are colonized by their chemosynthetic symbionts throughout their lifetime. Environ. Microbiol. 16:3699–3713.


Ott JA, Gruber-Vodicka HR, Leisch N, Zimmermann J (2014). Phylogenetic confirmation of the genus Robbea (Nematoda: Desmodoridae, Stilbonematinae) with the description of three new species. Syst Biodivers 12: 434-455.


Ott JA, Leisch N, Gruber-Vodicka HR (2014). Eubostrichus fertilis sp. n., a new marine nematode (Desmodoridae: Stilbonematinae) with an extraordinary reproductive potential from Belize, Central America. Nematology 16: 777-787.


Pende N, Leisch N, Gruber-Vodicka HR, Heindl NR, Ott J, den Blaauwen T, Bulgheresi S (2014). Size-independent symmetric division in extraordinarily long cells. Nat Commun 5: 4803.


Beinart, R.; Nyholm, S.; Dubilier, N.; Girguis, P. (2014). Intracellular Oceanospirillales inhabit the gills of the hydrothermal vent snail Alviniconcha with chemosynthetic, gamma-Proteobacterial symbionts, Environmental Microbiology Reports, 656–664.


Fagervold, S, Romano, C, Kalenitchenko, D, Borowski, C, Nunes-Jorge, A, Martin, D, Galand, P. (2014). Microbial communities in sunken wood are structured by wood-boring bivalves and location in a submarine canyon. PLoS One. 7;9(5):e96248. doi: 10.1371/journal.pone.0096248.


Koschinsky, A, Kausch, M, Borowski, C. Metal concentrations in the tissues of the hydrothermal vent mussel Bathymodiolus: Reflection of different metal sources. Marine Environmental Research Volume 95, Pages 62–73. (2014)


Mora-Lugo, R, Zimmermann, J, Rizk, A, Fernandez-Lahore, M. (2014) Development of a transformation system for Aspergillus sojae based on the Agrobacterium tumefaciens-mediated approach. Microbial genetics, genomics and proteomics, Volume 14, (2014)


Ott, J, Gruber-Vodicka, H, Leisch, N, Zimmermann, J. (2014). Phylogenetic confirmation of the genus Robbea (Nematoda: Desmodoridae, Stilbonematinae) with the description of three new species. Systematics and Biodiversity Volume 12, Issue 4.


Ott, J, Leisch, N, Gruber-Vodicka, H. (2014). Eubostrichus fertilis sp n., a new marine nematode (Desmodoridae: Stilbonematinae) with an extraordinary reproductive potential from Belize, Central America. Nematology 00:1-11. doi:10.1163/15685411-00002807.


Pende, N, Leisch, N, Gruber-Vodicka, H, Heindl, N, Ott, J, den Blaauwen, T, Bulgheresi, S. (2014). Size-independent symmetric division in extraordinarily long cells. Nature Communications 5, Article number: 4803 doi:10.1038/ncomms5803.


Petersen, J, Dubilier, N. (2014). Gene swapping in the dead zone. eLife. 3: e04600.


Russell, J, Dubilier, N, Rudgers, J.: Nature's microbiome: introduction. Mol Ecol. (6):1225-37. doi: 10.1111/mec.12676. (2014)


McFall-Ngai M, Hadfield MG, Bosch TCG, Carey HV, Domazet-Loso T, Douglas AE, Dubilier N, Eberl G, Fukami T, Gilbert SF, Hentschel U, King N, Kjelleberg S, Knoll AH, Kremer N, Mazmanian SK, Metcalf JL, Nealson K, Pierce NE, Rawls JF, Reid A, Ruby EG, Rumpho M, Sanders JG, Tautz D, Wernegreen JJ (2013). An­im­als in a bac­terial world, a new im­per­at­ive for the life sci­ences. Pro­ceed­ings of the Na­tional Academy of Sci­ences. 110(9): 3229-3236. doi: 10.1073/pnas.1218525110


Raggi L, Schubotz F, Hinrichs K-U, Dubilier N, Petersen JM (2013). Bac­terial sym­bionts of Bathymodiolus mus­sels and Escarpia tube­worms from Chapo­pote, an as­phalt seep in the south­ern Gulf of Mex­ico. En­vir­on­mental Mi­cro­bi­o­logy. Ad­vance on­line pub­lic­a­tion. doi:10.1111/1462-2920.12051


Wentrup C, Wendeberg A, Huang JY, Borowski C, Dubilier N (2013). Shift from wide­spread sym­biont in­fec­tion of dif­fer­ent host tis­sues to spa­tially re­stric­ted col­on­iz­a­tion of gill cells in early life stages of hy­dro­thermal vent mus­sels. ISME Journal. 7: 1244-1247. doi:10.1038/ismej.2013.5


Kleiner, M, Young JC, Shah M, VerBerkmoes NC, Dubilier N (2013). Meta­pro­teo­m­ics re­veals abund­ant trans­posase ex­pres­sion in mu­tu­al­istic en­dosym­bionts. mBio. 4(3): e00223-13. doi: 10.1128/mBio.00223-13


Marcon Y, Sahling H, Borowski C, dos Santos Ferreira C, Thal J, Bohrmann G (2013) Mega­faunal dis­tri­bu­tion and as­sess­ment of total meth­ane and sulf­ide con­sump­tion by mus­sel beds at Me­nez Gwen hy­dro­thermal vent, based on geo-ref­er­enced pho­to­m­o­sa­ics. Deep-Sea Re­search I 75, 93-109.


Kleiner M, Wentrup C, Lott C, Teeling H, Wetzel S, Young J, Chang YJ, Shah M, VerBerkmoes NC, Zarzycki J, Fuchs G, Markert S, Hempel K, Voigt B, Becher D, Liebeke M, Lalk M, Albrecht D, Hecker M, Schweder T, Dubilier N (2012). Meta­pro­teo­m­ics of a gut­less mar­ine worm and its sym­bi­otic mi­cro­bial com­munity re­veal un­usual path­ways for car­bon and en­ergy use. Pro­ceed­ings of the Na­tional Academy of Sci­ences. 109(19): 7148-7149.
doi: 10.1073/pnas.1121198109 (open ac­cess)


Kleiner M, Petersen JM and Dubilier N (2012). Con­ver­gent and di­ver­gent evol­u­tion of meta­bol­ism in sul­fur-ox­id­iz­ing sym­bionts and the role of ho­ri­zontal gene trans­fer. Cur­rent Opin­ion in Mi­cro­bi­o­logy 15:621–631.


Petersen JM, Wentrup C, Verna C, Knittel K, Dubilier N (2012). Ori­gins and evol­u­tion­ary flex­ib­il­ity of chemo­syn­thetic sym­bionts from deep-sea an­im­als. Bio­lo­gical Bul­letin 223: 123-137


van der Heijden K, Petersen JM, Dubilier N, Borowski C (2012). Ge­netic con­nectiv­ity between North and South Mid-At­lantic Ridge chemo­syn­thetic bi­valves and their sym­bionts. PLoS One 7(7): e39994. doi:10.1371/journal.pone.0039994


Kellermann MY, Schubotz F, Elvert M, Lipp JS, Birgel D, Prieto-Mollar X, Dubilier N, Hinrichs K-U (2012). Sym­biont-host re­la­tion­ships in chemo­syn­thetic mus­sels: A com­pre­hens­ive lipid bio­marker study. Or­ganic Geo­chem­istry 43, 112-124. doi:10.1016/j.orggeochem.2011.10.005


Wendeberg A, Zielinski FU, Borowski C, Dubilier N (2012). Ex­pres­sion pat­terns of mRNAs for meth­an­o­trophy and thio­trophy in sym­bionts of the hy­dro­thermal vent mus­sel Bathymodiolus puteoserpentis. ISME Journal 6, 104-112. doi:10.1038/ismej.2011.81


Gros O, Elisabeth NH, Gustave SDD, Caro A, Dubilier N (2012). Plas­ti­city of sym­biont ac­quis­i­tion throughout the life cycle of the shal­low-wa­ter trop­ical lu­cinid Codakia or­bic­u­lata (Mol­lusca: Bi­valvia). En­vir­on­mental Mi­cro­bi­o­logy 14, 1584-1595, doi:10.1111/j.1462-2920.2012.02748.x


Petersen JM, Zielinski FU, Pape T, Seifert R, Moraru C, Amann R, Hourdez S, Girguis PR, Wankel SD, Barbe V, Pelletier E, Fink D, Borowski C, Bach W, Dubilier N (2011). Hy­dro­gen is an en­ergy source for hy­dro­thermal vent sym­bi­oses. Nature 476, 176–180, doi:10.1038/nature10325


Hugler M, Petersen JM, Dubilier N, Imhoff JF, Sievert SM (2011). Path­ways of car­bon and en­ergy meta­bol­ism of the epi­bi­otic com­munity as­so­ci­ated with the deep-sea hy­dro­thermal vent shrimp Rimicaris exoculata. PLoS One 6, doi:e1601810.1371/journal.pone.0016018


Kleiner M, Woyke T, Ruehland C, Dubilier N (2011). The Olavius algarvensis meta­gen­ome re­vis­ited: les­sons learned from the ana­lysis of the low di­versity mi­cro­bial con­sor­tium of a gut­less mar­ine worm. In: Hand­book of Mo­lecu­lar Mi­cro­bial Eco­logy II; Meta­ge­n­om­ics in Dif­fer­ent Hab­it­ats. Ed: de Bruijn FJ. Wiley/ Black­well, doi: 10.1002/9781118010549.ch32


Zielinski FU, Gennerich H, Borowski C, Wenzhöfer F, Dubilier N (2011). In situ meas­ure­ments of hy­dro­gen sulf­ide, oxy­gen, and tem­per­at­ure in dif­fuse flu­ids of an ul­tramafic-hos­ted hy­dro­thermal vent field (Log­atchev, 14°45′N, Mid-At­lantic Ridge): Im­plic­a­tions for chemosym­bi­otic ba­thymo­di­olin mus­sels. Geo­chem­istry Geo­phys­ics Geo­sys­tems 12, Q0AE04, doi:10.1029/2011GC003632.


Petersen JM, Ramette A, Lott C, Cambon Bonavita M-A, Zbinden M, Dubilier N. (2010). Dual sym­bi­osis of the vent shrimp Rimicaris exoculata with fil­a­ment­ous gamma- and ep­si­lon­pro­teo­bac­teria at four Mid-At­lantic Ridge hy­dro­thermal vent fields. En­viron. Mi­cro­biol. 12: 2204-2218­doi:10.1111/ j.1462-2920.2009.02129.x


Ruehland C and Dubilier N. (2010) Gamma- and ep­si­lon­pro­teo­bac­terial ec­tosym­bionts of a shal­low-wa­ter mar­ine worm are re­lated to deep-sea hy­dro­thermal vent ec­tosym­bionts. En­vir­on­mental Mi­cro­bi­o­logy, 12: 2312–2326. doi: 10.1111/ j.1462-2920.2010.02256.x


Verna, C., Ramette, A., Wiklund, H., Dahlgren, T. G., Glover, A. G., Gaill, F. and Dubilier, N. (2010), High sym­biont di­versity in the bone-eat­ing worm Osedax mucofloris from shal­low whale-falls in the North At­lantic. En­vir­on­mental Mi­cro­bi­o­logy, 12: 2355–2370. doi: 10.1111/ j.1462-2920.2010.02299.x


Zielinski F, Dubilier N. (2010) Der Eu­k­a­ryoten-Zellkern als öko­lo­gis­che Nis­che für Bak­ter­ien. BioSpek­trum01-10 16 p.12-15


Petersen JM and Dubilier N. (2009) Sym­bi­otic meth­ane ox­id­izers. In: Hand­book of Hy­dro­car­bon and Lipid Mi­cro­bi­o­logy. Ed: Ken­neth M. Tim­mis. Springer Ver­lag, Heidel­berg, doi:10.1007/ 978-3-540-77587-4_145


Petersen JM and Dubilier N. (2009) Meth­an­o­trophic sym­bi­oses in mar­ine in­ver­teb­rates. En­viron. Mi­cro­biol. Re­ports (2009) 1(5), 319–335, doi:10.1111/ j.1758-2229.2009.00081.x


Zielinski FU, Pernthaler A, Duperron S, Raggi L, Giere O, Borowski C, Dubilier N. (2009) Wide­spread oc­cur­rence of an in­tra­nuc­lear bac­terial para­site in vent and seep ba­thymo­di­olin mus­sels. En­viron. Mi­cro­biol. 11: 1150-1167, doi:10.1111/ j.1462-2920.2008.01847.x


Dubilier N, Bergin C, Lott C. (2008) Sym­bi­otic di­versity in mar­ine an­im­als: the art of har­ness­ing chemo­syn­thesis. Nature Re­views Mi­cro­bi­o­logy 6: 725-740, doi:10.1038/ nr­mi­cro1992


Lösekann T, Robador A, Niemann H, Knittel K, Boetius A, Dubilier N. (2008) En­dosym­bi­oses between bac­teria and deep-sea siboglinid tube­worms from an Arc­tic cold seep (Haakon Mosby Mud Vol­cano, Bar­ents Sea). En­viron. Mi­cro­biol. 10: 3237-3254, doi:10.1111/ j.1462-2920.2008.01712.x


Martínez-García M, Stief P, Díaz-Valdés M, Wanner G, Ramos-Esplá A, Dubilier N, and Antón J. (2008). Am­mo­nia-ox­id­iz­ing Cren­ar­chae­ota and ni­tri­fic­a­tion in­side the tis­sue of a co­lo­nial as­cid­ian. En­viron. Mi­cro­biol. 10: 2991-300, doi:10.1111/ j.1462-2920.2008.01761.x


Ruehland C, Blazejak A, Lott C, Loy A, Erséus C, Dubilier N. (2008). Mul­tiple bac­terial sym­bionts in two spe­cies of co-oc­cur­ring gut­less mar­ine worms from Medi­ter­ranean sea grass sed­i­ments. En­viron. Mi­cro­biol. 10: 3404-3416, doi:10.1111/ j.1462-2920.2008.01728.x


Dubilier N. (2007) The search­light and the bucket of mi­cro­bial eco­logy. En­viron. Mi­cro­biol. 9: 2-3, doi:doi:10.1111/ j.1462-2920.2006.01222.x


Duperron S, Sibuet M, MacGregor BJ, Kuypers MMM, Fisher CR, Dubilier N. (2007) Di­versity, re­l­at­ive abund­ance, and meta­bolic po­ten­tial of bac­terial en­dosym­bionts in three Ba­thymo­di­olus mus­sel spe­cies from cold seeps in the Gulf of Mex­ico. En­viron. Mi­cro­biol. 9: 1423-1438, doi:10.1111/ j.1462-2920.2007.01259.x


Haase KM, Petersen S, Koschinsky A, Seifert R, Devey C, Dubilier N, Fretzdorff S, Garbe-Schönberg D, German CR, Giere O, Keir R, Kuever J, Lackschewitz K, Mawick J, Marbler H, Melchert B, Mertens C, Paulick H, Perner M, Peters M, Sander S, Schmale O, Stecher J, Strauss H, Süling J, Stöber U, Walter M, Weber S, Westernströer U, Yoerger D, Zielinski F (2007) Young vol­can­ism and re­lated hy­dro­thermal activ­ity at 5°S on the slow-spread­ing south­ern Mid-At­lantic Ridge. Geo­chem­istry Geo­phys­ics Geo­sys­tems 8: Vol. 8, Q11002, DOI 10.1029/ 2006GC001509


Musat N, Giere O, Gieseke A, Thiermann F, Amann R, Dubilier N. (2007) Mo­lecu­lar and mor­pho­lo­gical char­ac­ter­iz­a­tion of the as­so­ci­ation between bac­terial en­dosym­bionts and the mar­ine nem­at­ode As­tomonema sp. from the Ba­hamas. En­viron. Mi­cro­biol. 9: 1345-1353, doi:10.1111/ j.1462-2920.2006.01232.x


Pernice M, Wetzel S, Gros O, Boucher-Rodoni R, Dubilier N. (2007) En­ig­matic dual sym­bi­osis in the ex­cret­ory or­gan of Nautilus mac­romphalus (Ceph­alo­poda: Naut­iloidea). Proc. R. Soc. B. 274: 1143-1152, doi:10.1098/ rspb.2006.0353


Pradillon F, Schmidt A, Peplies J, Dubilier N. (2007) Spe­cies iden­ti­fic­a­tion of mar­ine in­ver­teb­rate early stages by whole – lar­vae in situ hy­brid­isa­tion of 18S ri­bosomal RNA. Mar. Ecol. Prog. Ser. 333: 103-116.


Woyke T, Teeling H, Ivanova NN, Richter M, Hunteman M, Gloeckner FO, Boffelli D, Barry KW, Shapiro HJ, Mussmann M, Bergin C, Ruehland C, Amann R, Anderson IJ, Szeto E, Kyrpides NC, Markowitz VM, Rubin EM, Dubilier N. (2006) Sym­bi­osis in­sights through meta­ge­n­omic ana­lysis of a mi­cro­bial con­sor­tium. Nature 443: 950-955, doi:10.1038/ nature05192


Blazejak A, Kuever J, Erséus C, Amann R, Dubilier N. (2006) Phylo­geny of 16S rRNA, ribu­lose 1,5-bi­sphos­phate carboxylase/ osy­genase, and ad­en­osine 5’-phos­pho­sulfate re­ductase genes from gamma- and al­phapro­teo­bac­terial sym­bionts in gut­less mar­ine worms (Oli­go­chaeta) from Ber­muda and Ba­hamas. Appl. En­viron. Mi­cro­biol. 72: 5527-5536, doi:10.1128/ AEM.02441-05


Da Silva SG, Gillan DC, Dubilier N, De Ridder, C. (2006) Char­ac­ter­iz­a­tion by 16S rRNA gene ana­lysis and in situ hy­brid­iz­a­tion of bac­teria liv­ing in the hindgut of a de­posit-feed­ing ech­in­oid (Ech­in­o­der­mata). J. Mar. Biol. As­soc. UK 86:1209-1213, doi:10.1017/ S0025315406014202


Dubilier N, Blazejak A, Ruehland C. (2006) Sym­bi­oses between bac­teria and gut­less mar­ine oli­go­chaetes. In: J. Over­mann (ed) Mo­lecu­lar Basis of Sym­bi­osis. Springer Ver­lag, New York. Pp 251-275, doi:10.1007/ 3-540-28221-1_12


Duperron S, Bergin C, Zielinski F, Pernthaler A, Dando P, McKiness ZP, DeChaine E, Cavanaugh CM, Dubilier N. 2006. A dual sym­bi­osis shared by two mus­sel spe­cies, Ba­thymo­di­olus azori­cus and B. pu­teo­serpentis (Bi­valvia: Mytil­idae), from hy­dro­thermal vents along the north­ern Mid-At­lantic Ridge. En­viron. Mi­cro­biol. 8: 1441-1447, doi:10.1111/ j.1462-2920.2006.01038.x


Musat N, Werner U, Kolb S, Dodenhof T, Knittel K, van Beusekom JEE, Dubilier N, Amann R. (2006) Mi­cro­bial com­munity struc­ture of sandy in­ter­tidal sed­i­ments in the North Sea, Sylt-Rømø Basin, Wad­den Sea. Syst. Appl. Mi­cro­biol. 29: 333-348, doi:10.1016/ j.syapm.2005.12.006


Ruehland C, Bergin C, Lott C, Dubilier N. (2006) Darm­lose mar­ine Würmer: Sym­bi­osen mit mik­robi­el­len Kon­sor­tien. BIOspek­trum 06:600-602


de Beer D, Wenzhöfer F, Ferdelman TG, Boehme SE, Huettel M, van Beusekom JEE, Böttcher ME, Musat N, Dubilier N. (2005) Trans­port and min­er­al­iz­a­tion rates in North Sea sandy in­ter­tidal sed­i­ments, Sylt-Rømø Basin, Wad­den Sea. Lim­nol. Ocean­ogr. 50: 113-127, Stable URL: http:// stable/ 3597885


Blazejak A, Erséus C, Amann R, Dubilier N. (2005) Co­ex­ist­ence of bac­terial sulf­ide-ox­id­izers, sulfate-re­du­cers, and spir­o­chetes in a gut­less worm (Oli­go­chaeta) from the Peru mar­gin. Appl. En­viron. Mi­cro­biol. 71: 1553-156, doi:10.1128/ AEM.71.3.1553-1561.2005


Duperron S, Nadalig T, Caprais J-C, Sibuet M, Fiala-Médioni A, Amann R, Dubilier N. (2005) Dual sym­bi­osis in a Ba­thymo­di­olus sp. mus­sel from a meth­ane seep on the Ga­bon con­tin­ental mar­gin (South­east At­lantic): 16S rRNA phylo­geny and dis­tri­bu­tion of the sym­bionts in gills. Appl. En­viron. Mi­cro­biol. 71: 1694-1700, doi:10.1128/ AEM.71.4.1694-1700.2005


Urakawa H, Dubilier N, Fujiwara Y, Cunningham DE, Kojima S, Stahl DA (2005) Hy­dro­thermal vent gast­ro­pods from the same fam­ily (Pro­van­nidae) har­bour ep­si­lon- and gamma-pro­teo­bac­terial en­dosym­bionts. En­viron. Mi­cro­biol. 7: 750-754, doi:10.1111/ j.1462-2920.2005.00753.x


Dubilier N. (2004) Mul­tiple bac­terial en­dosym­bionts in gut­less mar­ine worms: com­pet­it­ors or part­ners? Nova Acta Leo­pold­ina NF 88: 107-112


Gillan DC and Dubilier N. (2004) Novel epi­bi­otic Thio­thrix bac­terium on a mar­ine am­phi­pod. Appl. En­viron. Mi­cro­biol. 70: 3772-3775, doi:10.1128/ AEM.70.6.3772-3775.2004


Dubilier N, Mülders C, Ferdelman T, de Beer D, Pernthaler A, Klein M, Wagner M, Erséus C, Thiermann F, Krieger J, Giere O, and Amann R. (2001) Endosymbiotic sulphate-reducing and sulphide-oxidizing bacteria in an oligochaete worm. Nature 411: 298-302, doi:10.1038/35077067


Dubilier N, Amann R, Erséus C, Muyzer G, Park S, Giere O, and Cavanaugh CM. (1999) Phylo­gen­etic di­versity of bac­terial en­dosym­bionts in the gut­less mar­ine oli­go­chaete Olavius loi­sae (An­nel­ida). Mar. Ecol. Prog. Ser. 178: 271-280, doi:10.3354/​meps178271


Giere O, Preusse J-H, and Dubilier N. (1999) Tu­bi­ficoides be­ne­dii (Tu­bi­fi­cidae, Oli­go­chaeta) - a pi­on­eer in hyp­oxic and sulf­idic en­vir­on­ments. An over­view of ad­apt­ive path­ways. Hy­dro­bi­o­lo­gia 406: 235-241, doi:10.1023/​A:1003711914788


Dubilier N, Giere O, Distel DL, and Cavanaugh CM. (1995) Chemoauto­trophic bac­terial sym­bionts in a gut­less mar­ine worm (Oli­go­chaeta, An­nel­ida): Phylo­gen­etic 16S rRNA se­quence ana­lysis and in situ hy­brid­iz­a­tion. Appl. En­viron. Mi­cro­biol. 61: 2346-2350.


Dubilier N, Giere O and Grieshaber M. (1995) Mor­pho­lo­gical and eco­physiolo­gical ad­apt­a­tions of the mar­ine oli­go­chaete Tu­bi­ficoides be­ne­dii to sulf­idic sed­i­ments. Amer. Zool. 35: 163-173, Stable URL: http://​​stable/​3883973


Dubilier N. (1988) H2S - A set­tle­ment cue or a toxic sub­stance for Cap­i­tella sp. l lar­vae? Biol. Bull. 174: 30-38.


Giere O, Rhode B. and Dubilier N. (1988) Struc­tural pe­cu­li­ar­it­ies of the body wall of Tu­bi­ficoides be­ne­dii (Oli­go­chaeta) and pos­sible re­la­tions to its life in sulph­idic sed­i­ments. Zoomor­pho­logy 108: 29-39, doi:10.1007/​BF00312212


PhD Students

  • Lizbeth Sayavedra Camacho (2016) "Host-symbiont interactions and metabolism of chemosynthetic symbiosis in deep-sea Bathymodiolus mussels". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Adrien Assié (2016) “Deep se(a)quencing: A study of deep-sea ectosymbioses using next generation sequencing". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Juliane Wippler (2016) “Characterization of host-symbiont molecular interactions and evolutionary relationships in the gutless oligochaete Olavius algarvensis". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Mario Schimak (2016) "Transmission of bacterial symbionts in the gutless oligochaete Olavius algarvensis. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Judith Zimmermann (2015) "Diversity, specificity and evolutionary history of marine invertebrate symbioses and functions of the sulfur-oxidizing symbionts". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Manuel Kleiner (2012) "Metabolism and evolutionary ecology of chemosynthetic symbionts from marine invertebrates". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Cecilia Wentrup (2012) "Acquisition and Activity of Bacterial Symbionts in Marine Invertebrates". Fachbereich Biologie/Chemie, University of Bremen
  • Dennis Fink (2011) "Dynamics of Symbiont Abundance in Bathymodiolin Deep-Sea Symbioses". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Caroline Verna (2010) “Phylogeny and Diversity of Symbionts from Whale Fall Invertebrates”. International Max Planck Research School for Marine Microbiology, University of Bremen and University of Pierre and Marie Curie, Paris
  • Caroline Ruehland (2010) "Characterization of Bacterial Ecto- and Endosymbionts of Oligochaete Worms from Marine Sediments: Phylogeny and Metabolic Potential". Fachbereich Biologie/Chemie, University of Bremen
  • Luciana Raggi (2010) "Bacterial – Invertebrate Symbioses: From an Asphalt Cold Seep to Shallow Waters". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Jillian Petersen-Struck (2009) “Biogeography of bacterial symbionts from hydrothermal vent shrimp and mussels”. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Claudia Bergin (2009) "Molecular physiology of bacterial symbionts in gutless marine oligochaetes". Fachbereich Biologie/Chemie, University of Bremen.
  • Frank Zielinski (2008) "Geobiological coupling of hydrothermal vent fluids with endosymbiotic primary producers of Bathymodiolus mussels from hydrothermal vents on the Mid-Atlantic Ridge”. Fachbereich Biologie/Chemie, University of Bremen.
  • Niculina Musat (2006) "Molecular characterization of symbiotic associations between chemoautotrophic sulfur-oxidizing microorganisms and nematodes in shallow marine sediments". Fachbereich Biologie/Chemie, University of Bremen.
  • Sébastien Duperron (2005) "Bacterial symbioses in mytilid bivalves associated with cold seeps and hydrothermal vents: diversity, nutritional role, and influence of the environment". University of Paris 6, France. Joint PhD with Myriam Sibuet (IFREMER, France)
  • Anna Blazejak (2005) "Phylogenetic and functional characterization of symbiotic bacteria in gutless marine worms (Annelida, Oligochaeta)”. Fachbereich Biologie/Chemie, University of Bremen.

MSc Students

  • Tina Enders (2017) “Role of carbon monoxide in the biogeochemistry of Posidonia oceanica seagrass peat". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Maximillian Franke (2017) “Symbiont colonization in early developmental stages of the deep-sea mussel Bathymodiolus puteoserpentis". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Merle Ücker (2017) “Understanding microbial symbioses in bathymodiolin hybrid host species using metagenomics". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Moritz Janda (2017) “Mass spectrometry imaging based metabolomics of host-microbe interactions in marine invertebrates”. University of Bremen.
  • Anna Mankowski (2017) “Comparative and functional genomics of deltaproteobacterial symbionts of gutless oligochaetes". University of Bremen.
  • Pierre Methou (2016) “Expression of Olavius algarvensis respiratory pigments revealed through mRNA whole-mount in situ hybridization”. Master Sciences de l’Univers, Environnement, Ecologie Spécialité : EcoPhysiologie et EcoToxicologie.
  • Dolma Michellod (2016) "Metabolic analyses of symbioses between chemoautotrophic bacteria and marine invertebrates". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Miriam Brandt (2015) "Characterization and comparative study of the chemosynthethic symbiosis in gutless marine oligochaetes from Belize and Bermuda". University of Bremen.
  • Miguel Angel Gonzalez Porras (2015) "Probing the complexity of a deep-sea symbiosis: Establishing geneFISH as a technique to image symbiont strain-specific differences in metabolic potential". International MSc in Marine Biodiversity and Conservation. MSc program of consortium of 6 European universities.
  • Benedikt Geier (2015) "A correlative approach for combining multimodal imaging techniques in a 3D scenario". External student from the LMU Munich.
  • Anna Kemper (2015) "Symbiont metabolic potential and host symbiont interactions in the lucinid chemosynthetic symbiosis from Elba, Italy. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Rahel Yemanaberhan (2015) "Carbon incorporation and transfer in marine symbiotic worms". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Rebecca Ansorge (2014) “Strain diversity and genome evolution in chemoautotrophic symbionts of Bathymodiolus mussels”. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Oliver Jäckle (2014) “Experimental molecular and biochemical characterization of the Paracatenula symbiosis”. International Max Planck Research School for Marine Microbiology, University of Bremen
  • Kwee Boon Brandon Seah (2013) “Bacterial ectosymbionts of the ciliate Kentrophoros”. International Max Planck Research School for Marine Microbiology. University of Bremen
  • Miriam Sadowski (2013) “Molecular characterization of ectosymbiotic bacteria from nematodes in a shallow water system”. International Max Planck Research School for Marine Microbiology. University of Bremen
  • Laura Gallego Valle (2012) "Microdiversity in host-associated and free-living symbionts of Bathymodiolus mussels from Mid-Atlantic Ridge". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Lizbeth Sayavedra Camacho (2012) "Comparative genomics of symbiotic and free-living chemoautotrophic bacteria". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Juliane Wippler (2011) "Analysis of mobile DNA in endosymbionts of the gutless marine oligochaete worm Olavius algarvensis". International Max Planck Research School for Marine Microbiology. University of Bremen.
  • Judith Zimmermann (2010) "Molecular characterization of a vestimentiferan tubeworm and its endosymbiotic bacteria from a hydrothermal vent in the Mediterranean Sea". University of Bremen.
  • Dennis Fink (2008) “Distribution, abundance and productivity of endosymbionts in the deep-sea mussel Bathymodiolus”. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Karina Röse (2008) “Symbiosis between bacteria and bathymodioline mussels at hydrothermal vent and cold seep sites”. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Luciana Raggi (2007) “Molecular studies of two different bacterial symbioses in invertebrates: diversity and biogeography”. International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Jillian Petersen-Struck (2006) "Molecular studies of deep-sea invertebrate symbioses: characterisation, geobiological coupling, and biogeography". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Nancy Brewig (2006) "Molecular biological characterization of the symbionts from the gutless marine oligochaete Inanidrilus exumae". University of Hamburg.
  • Amelia Rotaru (2005) "Genomic analysis of the endosymbiotic communities of a gutless marine worm (Olavius algarvensis)". International Max Planck Research School for Marine Microbiology, University of Bremen.
  • Mirjam Perner (2003) "Biogechemical and microbiological characterisation of marine sediments in Elba - a contribution to an ecosystematic analysis of oligochaetes with bacterial symbionts". University of Hamburg.
  • Christina Zaluski (2003) "Molecular biological characterisation of bacterial symbionts in the marine gutless oligochaete Inandrilus leukodermatus". University of Hamburg.
  • Claudia Bergin (2002) "Characterisation of stabile carbon isotopes in tissues and RNA of mussels with endosymbiotic bacteria". University of Bremen.
  • Anna Blazejak (2001) "Molecular characterisation of bacteria associated with marine oligochaetes (Annelida)". Technical University Berlin.
  • Steffen Kolb (1999) "Abundances and vertical distribution of sulfate-reducing and chemolithotrophic sulfur-oxdizing bacteria in sandy Wadden Sea sediments". University of Bremen.
  • Caroline Rühland (1999) "Molecular characterization of bacteria associated with marine oligochaetes (Annelida)". University of Hamburg.
  • Arnd Prilip (1999) "Characterisation of ectosymbionts of marine nematodes from the genus Leptonemella and free-living sulfur-oxidizing bacteria with microbiological and molecular methods". University of Bremen.
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