Development and application of smart DNA probes for multiplexed super-resolution microscopy
Fluorescence microscopy, an important and widely used tool in biological research, has witnessed a true renaissance since the invention of methods circumventing the so-called diffraction limit, namely super-resolution techniques. In 2014 the Nobel Prize in Chemistry was awarded for this breakthrough. In resonance with these exciting advancements, my PhD and postdoctoral work combines advanced high-resolution microscopy with novel approaches from the field of DNA Nanotechnology to push the limits of light microscopy and apply it to cell-biological and microbiological research. In this presentation, I will describe current advances of DNA-based super-resolution microscopy regarding spectrally unlimited multiplexing, novel immuno-labeling strategies, proximity detection, spatial imaging range (from close to the coverslip to whole eukaryotic cells and potentially tissues), and image acquisition speed.
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