My Main Research Interests
The research in my group focuses on the chemical interactions between bacterial symbionts and their eukaryotic hosts. I am convinced Mass Spectrometry based Metabolomics can provide us with a detailed view into the metabolic interactions.
My group develops high-resolution Spatial Imaging Methods for in situ measurements of metabolites in host-microbe systems named spatial metabolomics.
Our major approaches are:
- spatial metabolomics on host-microbe systems
- Mass spectrometry Imaging on the µm scale
- correlative imaging approaches,
- e.g. combining MALDI-MSI with FISH to map bacteria
- 3D scanning approaches like µCT to get 3D anatomy of hosts
- environmental metabolomics
- marine metabolomics, measure metabolites in seawater
- tissue extracts of animals, plants and microorganisms directly sampled in the field
- sediment porewater metabolites
- stable isotope tracer experiments
- following the fate of 13C or deuterated metabolites in symbiotic systems with MS