Dr. Silvia Vidal Melgosa

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MARUM MPG Bridge Group Marine Glycobiology

MPI for Marine Microbiology
Celsiusstr. 1
D-28359 Bremen




+49 421 2028-7360

Dr. Silvia Vidal Melgosa

Re­search In­terests

  • Marine carbon cycle
  • Marine glycobiology
  • Polysaccharide composition of microalgae and their exudates
  • Cell wall biology
  • Carbohydrate-active enzymes and carbohydrate-specific molecular probes


  • Vidal-Melgosa, S., Sichert, A., Francis, T.B., Bartosik, D., Niggemann, J., Wichels, A., Willats, W.G.T., Fuchs, B.M., Teeling, H., Becher, D., Schweder, T., Amann, R., Hehemann, J. H. (2021). Diatom fucan polysaccharide precipitates carbon during algal blooms. Nature Communications, 12(1), 1150.
  • Guo, S., Vance, T.D.R., Zahiri, H., Eves, R., Stevens, C., Hehemann, J.-H., Vidal-Melgosa, S., Davies, P.L. (2021). Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multi-species biofilm formation. mBio(Accepted).
  • Parsons, H.T., Stevens, T.J., McFarlane, H.E., Vidal-Melgosa, S., Griss, J., Lawrence, N., Butler, R., Sousa, M.M.L., Salemi, M., Willats, W.G.T., Petzold, C.J., Heazlewood, J.L., Lilley, K.S. (2019). Separating Golgi proteins from cis to trans reveals underlying properties of cisternal localization. The Plant Cell, 31(9), 2010-2034.
  • Koch H., Dürwald A., Schweder T., Noriega-Ortega B., Vidal-Melgosa S., Hehemann J.-H., Dittmar T., Freese H.M., Becher D., Simon M., Wietz M. (2019). Biphasic cellular adaptations and ecological implications of Alteromonas macleodii degrading a mixture of algal polysaccharides. The ISME Journal, 13(1), 92-103.
  • Mystkowska, A.A., Robb, C., Vidal-Melgosa, S., Vanni, C., Fernandez‐Guerra, A., Höhne, M., Hehemann, J.-H. (2018). Molecular recognition of the beta‐glucans laminarin and pustulan by a SusD‐like glycan‐binding protein of a marine Bacteroidetes. The FEBS Journal, 285(23), 4465-4481.
  • Baum, A., Dominiak, M., Vidal-Melgosa, S., Willats, W.G.T., Søndergaard, K.M., Hansen, P.W., Meyer, A.S., Mikkelsen, J.D. (2017). Prediction of pectin yield and quality by FTIR and carbohydrate microarray analysis. Food and Bioprocess Technology, 10(1), 143-154.
  • Kračun, S.K., Fangel, J.U., Rydahl, M.G., Pedersen, H.L., Vidal-Melgosa, S., Willats, W.G.T. (2017). Carbohydrate microarray technology applied to high-throughput mapping of plant cell wall glycans using comprehensive microarray polymer profiling (CoMPP). High-Throughput Glycomics and Glycoproteomics. Methods in Molecular Biology, 1503, 147-165.
  • Venditto I., Luis A.S., Rydahl M., Schückel J., Fernandes V.O., Vidal-Melgosa S., Bule P., Goyal A., Pires V.M., Dourado C.G., Ferreira L.M., Coutinho P.M., Henrissat B., Knox J.P., Baslé A., Najmudin S., Gilbert H.J., Willats W.G., Fontes C.M. (2016). Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition. Proceedings of the National Academy of Sciences, 113(26), 7136-7141.
  • Vidal-Melgosa, S., Pedersen, H.L., Schückel, J., Arnal, G., Dumon, C., Amby, D., Monrad, R.N., Westereng, B., Willats, W.G.T. (2015). A new versatile microarray-based method for high-throughput screening of carbohydrate-active enzymes. The Journal of Biological Chemistry, 290(14), 9020-9036.
  • Johnsen, H.R., Striberny, B., Olsen, S., Vidal-Melgosa, S., Fangel, J.U., Willats, W.G.T., Rose, J.C., Krause, K. (2015). Cell wall composition profiling of parasitic giant dodder (Cuscuta reflexa) and its hosts: a priori differences and induced changes. New Phytologist, 207(3), 805-816.
  • Feng, T., Nyffenegger, C., Højrup, P., Vidal-Melgosa, S., Yan, K.P., Fangel, J.U., Meyer, A.S., Kirpekar, F., Willats, W.G., Mikkelsen, J.D. (2014). Characterization of an extensin-modifying metalloprotease: N-terminal processing and substrate cleavage pattern of Pectobacterium carotovorum Prt1. Applied Microbiology and Biotechnology, 98(24), 10077-10089.
  • Dominiak, M., Søndergaard, K.M., Wichmann, J., Vidal-Melgosa, S., Willats, W.G.T., Meyer, A.S., Mikkelsen, J.D. (2014). Application of enzymes for efficient extraction, modification, and development of functional properties of lime pectin. Food Hydrocolloids, 40, 273-282.
  • Agger, J.W., Isaksen, T., Várnai, A., Vidal-Melgosa, S., Willats, W.G.T., Ludwig, R., Horn, S.J., Eijsink, V.G.H., Westereng, B. (2014). Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation. Proceedings of the National Academy of Sciences, 111, 6287-6292.
  • Fangel, J.U., Pedersen, H.L., Vidal-Melgosa, S., Ahl, L.I., Salmean, A.A., Egelund, J., Rydahl, M.G., Clausen, M.H., Willats, W.G.T. (2012). Carbohydrate microarrays in plant science. High-Throughput Phenotyping in Plants. Methods in Molecular Biology, 918, 351-362.


  • Vidal-Melgosa, S., Hehemann, J.-H. (2019). Fucoidans from diatoms. International patent. Publication number WO2019211442, filed 4 May 2018. Publication date: 07/11/2019.
  • Willats, W.G.T., Vidal-Melgosa, S. (2013). High throughput screening of glycosyl hydrolase enzymes. International patent. World Intellectual Property Organization. Publication number WO2013135245. Publication date: 19/09/2013.
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