Forschungsgruppe Metabolische Interaktionen

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We use modern mass-spectrometry methods to understand which molecules are involved in marine host-microbe systems, how different metabolites shape ecological communities, and how the symbiotic partners respond metabolically to environmental changes.

The research in this lab is constantly driven by method developments like high-resolution mass-spectrometry imaging to reveal the spatial metabolome of microbial systems. Our expertise is microbial metabolomics with a special focus on marine systems.


Dr. Manuel Liebeke

MPI for Marine Microbiology
Celsiusstr. 1
D-28359 Bremen




+49 421 2028-8220

Dr. Manuel Liebeke
Research Group Metabolic Interactions 2021
Research Group Metabolic Interactions 2021

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Sea4Society Project is Underway


In­no­va­ti­ve und ge­sell­schaft­lich ak­zep­tier­te An­sät­ze ent­wi­ckeln, um das na­tür­li­che Po­ten­zi­al für Koh­len­stoffspei­che­rung in ve­ge­ta­ti­ons­rei­chen Küs­te­nöko­sys­te­men zu ver­bes­sern: So lau­tet das Ziel des neu­en For­schungs­ver­bundssea4soCiety, an dem das Bre­mer Ma...

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Michellod, D., Bien, T., Birgel, D., Jensen, M., Kleiner, M., Fearn, S., Zeidler, C., Gruber-Vodicka, H. R., Dubilier, N., Liebeke, M. 2022. "De novo phytosterol synthesis in animals" bioRxiv; doi:
Geier BOetjen JRuth Steiner BPolikarpov M, Gruber-Vodicka HR, Liebeke M2021. Connecting structure and function from organisms to molecules in small-animal symbioses through chemo-histo-tomography. PNAS. 118 (27) e2023773118; 10.1073 / pnas.2023773118
Janda M, Seah BKB, Jakob D, Beckmann J, Geier B, and Liebeke M. 2021. Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets. Analytical Chemistry. 93 (24): 8399-8407. 10.1021 / acs.analchem.0c04720 
Geier, B., Sogin, E., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N. & Liebeke M. 2020. Spatial metabolomics of in situ host - microbe interactions at the micrometer scale. Nature Microbiology.
Sogin EM, Puskás E, Dubilier N, Liebeke M. 2019. Marine Metabolomics: a method for nontargeted measurement of metabolites in seawater by gas chromatography - mass spectrometry. mSystems 4 (6): e00638-19. 10.1128 / mSystems.00638-19


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